Neuroimmunology Laboratory

Neuroimmunology laboratory under the department of neurology at Amrita Hospital, Kochi is the first of its kind in India- a dedicated comprehensive testing facility for autoimmune neurological disorders under a trained clinical autoimmune neurologist. These disorders can be associated with a cancer (paraneoplastic) as well without cancer association (non-paraneoplastic).    

If properly investigated and diagnosed as an autoimmune neurological syndrome, it becomes potentially treatable and often fully reversible. Here comes the importance of comprehensive neuroimmunology service which can provide an early diagnosis.

Our aim is to provide a world class testing facility, define the spectrum of these disorders in our country as well as to disseminate information among the physician community. We are planning to develop a nationwide registry for autoimmune neurological disorders and to develop a bio bank for these disorders in collaborations with physicians and institutions across the country.     

When to suspect autoimmune etiology?

Here is a rough guideline about when to suspect an autoimmune neurological disorder-The clinical presentation can range from encephalitis, seizures, cognitive decline, optic neuritis, stroke like episodes, behavioral symptoms like psychosis, brainstem encephalitis characterized by cranial nerve and pyramidal involvement, ataxia, movement disorders like chorea and myoclonus ,dyskinesias, cerebellar ataxia, myelopathy, plexopathy, radiculopathy, neuropathy, autonomic neuropathy, myopathy and neuromuscular conduction defect-myasthenia.

Though the classical description of VGKC is limbic encephalitis and Moorvan's syndrome, the other presentations like PCD, GI dysmotility, parkinsonism, tremor, chorea, sensory motor neuropathy, hyponatremias, dyssomnia , hyperphagia, facio brachial dystonic seizure, other seizures and presentation mimicking CJD are well described. NMDA receptor antibodies classically associated with Psychiatric features and memory loss, orofacial dyskinesia, choreoathetoid movements, abnormal posturing or increased tone, catatonic state and central hypoventilation.

NMO IgG has expanded the spectrum of NMO to include optic neuritis and myelitis into NMO spectrum of disorder without the classical presentation of eye and spine involvement.     
 

Autoimmune etiology should be strongly sought in all neurological syndromes of unexplained etiology.

Paraneoplastic/autoimmune etiology should be considered in subacute sensory neuronopathy, cerebellar ataxia, limbic encephalitis, opsoclonus/myoclonus, encephalomyelitis, chronic gastrointestinal pseudo-obstruction and Lambert Eaton myasthenic syndrome.

Paraneoplastic antibodies are cancer specific, not disease-specific. Hence we discourage testing for single antibodies in the panel. Sometimes same patient can have multiple antibodies which in fact help us to locate cancer easily.

1. Acetylcholine Receptor antibody quantitation in Serum
   TAT 7 Working days
2. Adenylate Kinase 5 antibody in CSF
   TAT 48 working hours
3. Adenylate Kinase 5 antibody in Serum
   TAT 48 working hours
4. Agrin antibody quantitation in Serum
   TAT 7 working days
5. Alpha Synuclein quantitation in CSF
   TAT 7 Working days
6. Alpha Synuclein quantitation in Serum
   TAT 7 Working days
7. Autoimmune Atypical Parkinsonism antibody panel in CSF
   • ANNA-1(anti-Hu) Anti Neuronal Nuclear Antibody-1.
   • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody -2.
   • ANNA-3 Anti Neuronal Nuclear Antibody- 3.
   • AGNA-1 Anti Glial Nuclear Antibody-1.
   • PCA-2 Purkinje Cell Cytoplasmic Antibody-2.
   • PCA-Tr Purkinje Cell Cytoplasmic Antibody-Tr.
   • Amphiphysin Antibody
   • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody.
   • Ma2/Ta Antibody.
   • IgLON5 Antibody
   • LGI-1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
   • CASPR-2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
   • Unclassified Neuronal Antibody
     TAT 24 working hours
8. Autoimmune Atypical Parkinsonism antibody panel in Serum
   • ANNA-1 (anti-Hu) Anti Neuronal Nuclear Antibody-1.
   • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody -2.
   • ANNA-3 Anti Neuronal Nuclear Antibody -3.
   • AGNA-1 Anti Glial Nuclear Antibody-1.
   • PCA-2 Purkinje Cell Cytoplasmic Antibody-2.
   • PCA-Tr Purkinje Cell Cytoplasmic Antibody-Tr.
   • Amphiphysin Antibody.
   • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody.
   • Ma2/Ta Antibody
   • IgLON5 Antibody
   • LGI- 1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
   • CASPR-2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
   • Unclassified Neuronal Antibody
     TAT 24 working hours
9. Autoimmune Dementia Evaluation Panel – Optimised
   • ANNA-1 (anti-Hu) Anti Neuronal Nuclear Antibody1 in Serum
   • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody 2 in Serum
   • ANNA-3 Anti Neuronal Nuclear Antibody 3 in Serum
   • AGNA-1 Anti Glial Nuclear Antibody-1 in Serum
   • PCA-2 Purkinje Cell Cytoplasmic Antibody-2 in Serum
   • PCA-Tr Purkinje Cell Cytoplasmic Antibody-Tr in Serum
   • Amphiphysin Antibody in Serum
   • CRMP-5{Collapsin Response Mediator Protein-5} (Anti CV-2) Antibody in Serum
   • Ma2/Ta Antibody in Serum
   • GFAP Antibody in CSF
   • GABA A Receptor Antibody in Serum
   • DPPX-6 Receptor Antibody in Serum
   • Glycine Receptor Antibody in Serum
   • IgLON5 Antibody in Serum
   • LGI-1(Leucine-rich glioma- inactivated Protein-1) Antibody (VGKC associated) in Serum
   • CASPR-2(Contactin-associated protein-2) Antibody (VGKC associated) in Serum
   • NMDA (NR1) Receptor Antibody in CSF
   • AMPA1 Receptor Antibody in CSF
   • AMPA2 Receptor Antibody in CSF
   • GABA B Receptor Antibody in CSF
   • Zic 4 Antibody in Serum
   • Voltage-Gated Calcium Channel (VGCC) Antibody quantitation in Serum
   • Unclassified Neuronal Antibody in Serum
     TAT 7 Working days
10. Autoimmune Dementia Evaluation Panel in CSF
    • ANNA-1(anti-Hu) Anti Neuronal Nuclear Antibody-1.
    • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody -2.
    • ANNA-3 Anti Neuronal Nuclear Antibody- 3.
    • AGNA-1 Anti Glial Nuclear Antibody-1.
    • PCA-2 Purkinje Cell Cytoplasmic Antibody-2.
    • PCA-Tr Purkinje Cell Cytoplasmic Antibody-Tr.
    • Amphiphysin Antibody.
    • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody.
    • Ma2/Ta Antibody
    • GABA A Receptor Antibody
    • GFAP Antibody
    • DPPX-6 Receptor Antibody
    • Glycine Receptor Antibody
    • IgLON5 Antibody
    • LGI-1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
    • CASPR-2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
    • NMDA (NR1) Receptor Antibody
    • AMPA 1 Receptor Antibody
    • AMPA 2 Receptor Antibody
    • GABA B Receptor Antibody
    • Zic 4 Antibody
    • Unclassified Neuronal Antibody
      TAT 48 Working hours
11. Autoimmune Dementia Evaluation Panel in Serum
    • ANNA-1 (anti-Hu) Anti Neuronal Nuclear Antibody-1.
    • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody -2.
    • ANNA-3 Anti Neuronal Nuclear Antibody -3.
    • AGNA-1 Anti Glial Nuclear Antibody-1.
    • PCA-2 Purkinje cell Cytoplasmic Antibody-2.
    • PCA-Tr Purkinje cell Cytoplasmic Antibody-Tr.
    • Amphiphysin Antibody.
    • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody.
    • Ma2/Ta Antibody
    • GABA A Receptor Antibody
    • GFAP Antibody
    • DPPX -6 Receptor Antibody
    • Glycine Receptor Antibody
    • IgLON5 Antibody
    • LGI-1(Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
    • CASPR-2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
    • NMDA (NR1) Receptor Antibody
    • AMPA 1 Receptor Antibody
    • AMPA 2 Receptor Antibody
    • GABA B Receptor Antibody
    • Voltage-Gated Calcium Channel (VGCC) Antibody quantitation
    • Zic 4 Antibody
    • Unclassified Neuronal Antibody
      TAT 7 Working days
12. Autoimmune Encephalitis Panel of antibodies in CSF
    • GABA B Receptor Antibody
    • LGI 1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
    • CASPR 2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
    • AMPA 1 Receptor Antibody
    • AMPA 2 Receptor Antibody
    • NMDA (NR1) Receptor Antibody
      TAT 24 working hours
13. Autoimmune Encephalitis Panel of antibodies in Serum
    • GABA B Receptor Antibody
    • LGI 1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
    • CASPR 2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
    • AMPA 1 Receptor Antibody
    • AMPA 2 Receptor Antibody
    • NMDA (NR1) Receptor Antibody
      TAT 24 working hours
14. Autoimmune Epilepsy Profile in CSF
    • ANNA-1 (anti-Hu) Anti Neuronal Nuclear Antibody-1.
    • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody 2.
    • ANNA-3 Anti Neuronal Nuclear Antibody 3.
    • AGNA-1 Anti Glial Nuclear Antibody-1.
    • PCA-2 Purkinje cell Cytoplasmic Antibody-2.
    • PCA-Tr Purkinje cell Cytoplasmic Antibody-Tr.
    • Amphiphysin Antibody.
    • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody.
    • Ma2/Ta Antibody
    • LGI-1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
    • CASPR-2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
    • NMDA (NR1) Receptor Antibody
    • AMPA 1 Receptor Antibody
    • AMPA 2 Receptor Antibody
    • GABA B Receptor Antibody
    • GABA A Receptor Antibody
    • GFAP Antibody
    • DPPX-6 Receptor Antibody
    • Glycine Receptor Antibody
    • Unclassified Neuronal Antibody
      TAT 48 working hours
15. Autoimmune Epilepsy Profile in Serum
    • ANNA-1 (anti-Hu) Anti Neuronal Nuclear Antibody-1.
    • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody 2.
    • ANNA-3 Anti Neuronal Nuclear Antibody 3.
    • AGNA-1 Anti Glial Nuclear Antibody-1.
    • PCA-2 Purkinje cell Cytoplasmic Antibody-2.
    • PCA-Tr Purkinje cell Cytoplasmic Antibody-Tr.
    • Amphiphysin Antibody.
    • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody.
    • Ma2/Ta Antibody
    • LGI-1 (Leucine-rich Glioma- Inactivated Protein-1) Antibody (VGKC associated)
    • CASPR-2 (Contactin-Associated Protein-2) Antibody (VGKC associated)
    • NMDA (NR1) Receptor Antibody
    • AMPA1 Receptor Antibody
    • AMPA2 Receptor Antibody
    • GABA B Receptor Antibody
    • GABA A Receptor Antibody
    • GFAP Antibody
    • DPPX-6 Receptor Antibody
    • Glycine Receptor Antibody
    • Unclassified Neuronal Antibody
      TAT48 working hours
16. Autoimmune Movement Disorder Evaluation panel in CSF
    • Adaptor protein -3B2 antibody detection
    • Glial fibrillary acidic protein antibody detection
    • Homer -3 antibody detection
    • IgLON 5 antibody detection
    • Inositol 1, 4, 5-trisphosphate receptor type 1 antibody detection
    • Kelch –like protein 11 antibody detection
    • mGlur 2 (metabotrophic glutamate receptor 2) antibody detection
    • mGlur 1 (metabotrophic glutamate receptor 1) antibody detection
    • NIF(Neuronal intermediate filament) antibody detection
    • Neurochondrin antibody detection
    • Septin 5 antibody detection
    • Sez6L2(Seizure related 6 homologs like 2) antibody detection
    • TRIM(tripartite motif containing) 9 and 67 antibody detection
    • CASPR 2 antibody detection
    • LGI 1 antibody detection
      TAT48 working hours
17. Autoimmune Movement Disorder Evaluation panel in Serum
    • Adaptor protein -3B2 antibody detection
    • Glial fibrillary acidic protein antibody detection
    • Homer -3 antibody detection
    • IgLON 5 antibody detection
    • Inositol 1, 4, 5-trisphosphate receptor type 1 antibody detection
    • Kelch –like protein 11 antibody detection
    • mGlur 2 (metabotrophic glutamate receptor 2) antibody detection
    • mGlur 1 (metabotrophic glutamate receptor 1) antibody detection
    • NIF(Neuronal intermediate filament) antibody detection
    • Neurochondrin antibody detection
    • Septin 5 antibody detection
    • Sez6L2(Seizure related 6 homologs like 2) antibody detection
    • TRIM(tripartite motif containing) 9 and 67 antibody detection
    • CASPR 2 antibody detection
    • LGI 1 antibody detection
      TAT48 working hours
18. Autoimmune Neuropathy Evaluation with Sulfatide antibody(IgM) panel
    • Neurofascin 140 antibody quantitation in Serum
    • Neurofascin 155 antibody quantitation in Serum
    • Neurofascin 186 antibody quantitation in Serum
    • MAG antibody -IgG quantitation in Serum
    • Neuronal antibody-detection in Serum
    • VGKC antibody detection (LGI1&CASPR2) in Serum
    • GAD 65 antibody quantitation in Serum
    • Sulfatide IgM antibody quantitation in Serum
      TAT 15 Working days                  
19. CARP VIII (Carbonic Anhydrase – Related Protein VIII) antibody detection in CSF
    TAT 48 working hours
20. CARP VIII (Carbonic Anhydrase – Related Protein VIII) antibody detection in Serum
    TAT 48 working hours
21. CASPR1 (Anti Contactin Associated Protein 1 Antibody) quantitation in serum
    TAT 7 Working days 
22. Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Evaluation panel in Serum
    • Neurofascin 140 antibody quantitation
    • Neurofascin 155 antibody quantitation
    • Neurofascin 186 antibody quantitation
    • Contactin 1 antibody quantitation
    • CASPR1 antibody- quantitation
    • Sulfatide IgM antibody quantitation
    • MAG antibody - quantitation
      TAT 7 Working days 
23. CNS inflammation evaluation panel
    • Serum albumin quantitation
    • Serum IgG quantitation
    • CSF albumin quantitation
    • CSF IgG quantitation
    • CSF IgG index- formula-based calculation
    • CSF IgG synthesis rate- formula-based calculation
    • CSF IgG Intrathecal synthesis rate- formula-based calculation
    • Albumin index- formula-based calculation
    • Serum Oligoclonal Bands
    • CSF Oligoclonal Bands
      Paired Serum and CSF samples are necessary.
      CSF sample to be collected in polypropylene tube
      TAT 7 working days
24. CNS inflammation evaluation panel- Extended
    • Serum albumin quantitation
    • Serum IgG quantitation
    • CSF albumin quantitation
    • CSF IgG quantitation
    • CSF IgG index- formula-based calculation
    • CSF IgG synthesis rate- formula-based calculation
    • CSF IgG Intrathecal synthesis rate- formula-based calculation
    • Albumin index- formula-based calculation
    • CSFIgG/ CSF albumin ratio
    • Serum Oligoclonal Bands
    • CSF Oligoclonal Bands
    • Serum Neuronal antibody
    • CSF Neuronal antibody
      Paired Serum and CSF samples are necessary.
      CSF sample to be collected in polypropylene tube
      TAT 7 working days 
25. Contactin 1 antibody quantitation in Serum
    TAT 7 working days
26. CSF biomarkers of Alzheimer’s disease panel
    • Phospho-Tau(181P)quantitation
    • Tau protein quantitation
    • βamyloid (1-42)quantitation
    • βamyloid (1-40)quantitation in CSF
    • CSF pTau/Aβ42 ratio
    • CSF tau/Aβ42
    • Aβ42/ Aβ40
    • CSF ptau / t tau ratio
      TAT 7 working days
27. DPPX -6 (Dipeptidyl Aminopeptidase like Protein 6) antibody detection in CSF
    TAT 48working hours
28. DPPX -6 (Dipeptidyl Aminopeptidase like Protein 6) antibody detection in Serum
    TAT 48working hours      
29. 29. GABA A receptor antibody detection in CSF
    TAT 48 working hours
30. GABA A receptor antibody detection in Serum
    TAT 48 working hours
31. GABA B receptor antibody detection in CSF
    TAT 24 working hours
32. GABA B receptor antibody detection in Serum
    TAT 24 working hours
33. Ganglioside Antibody Evaluation Panel in Serum
    •  Ganglioside IgG in Serum (GD1b, GQ1b and GM1)
    •  Ganglioside IgM in Serum (GD1b, GQ1b and GM1)
      TAT 48working hours
34. Ganglioside Antibody Evaluation Panel in Serum – IgG and IgM mix (Gangliocombi) to GM1, GD1b and GQ1b - (GD1b-IgG & IgM, GQ1b IgG & IgM, GM1-IgG & IgM).
    TAT 24 working hours
35. GFAP (Glial Fibrillary Acidic Protein) antibody detection in CSF
    TAT 48working hours
36. GFAP (Glial Fibrillary Acidic Protein) antibody detection in Serum
    TAT 48 working hours
37. GAD 65 (Glutamic Acid Decarboxylase 65) antibody detection in CSF
    TAT 48 working hours
38. Glycine receptor antibody detection in CSF
    TAT 48 working hours
39. Glycine receptor antibody detection in Serum
    TAT 48 working hours                                                         
40. .HMGCoA Reductase anibody quantitation in Serum
    TAT 7 working days                                                                       
41. HOMER3 (Homer protein homolog 3) antibody detection in CSF
    TAT 48 working hours
42. HOMER3 (Homer protein homolog 3) antibody detection in Serum
    TAT 48 working hours
43. IgLON5 antibody detection in CSF
    TAT 24 working hours
44. IgLON5 antibody detection in Serum
    TAT 24 working hours
45. ITPR1 (Inositol 1 4 5-trisphosphate receptor type 1) antibody detection in CSF
    TAT 48 working hours
46. ITPR1 (Inositol 1 4 5-trisphosphate receptor type 1) antibody detection in Serum
    TAT 48 working hours
47. KLHL11 (Kelch – like protein11) antibody detection in CSF
    TAT 48 working hours
48. KLHL11 (Kelch – like protein11) antibody detection in Serum
    TAT 48 working hours
49. LRP4 (Low density Lipoprotein Receptor related Protein 4) antibody quantitation in Serum
    TAT 7 working Days
50. MAG (Myelin Associated Glycoprotein) antibody quantitation in Serum
    TAT 7 Working days
51. mGlur 1(metabotrophic glutamate receptor 1) antibody detection in CSF
    TAT 48 working hours
52. mGlur 1 (metabotrophic glutamate receptor 1) antibody detection in Serum
    TAT 48 working hours
53. mGlur 3 (metabotrophic glutamate receptor 3) antibody detection in CSF
    TAT 48 working hours
54. mGlur 3 (metabotrophic glutamate receptor 3) antibody detection in Serum
    TAT 48 working hours
55. mGlur 5(metabotrophic glutamate receptor 5) antibody detection in CSF
    TAT 48 working hours
56. mGlur 5 (metabotrophic glutamate receptor 5) antibody detection in Serum
    TAT 48 working hours
57. MOG (Myelin Oligodendrocyte Glycoprotein) antibody detection in CSF
    TAT 24 working hours
58. MOG (Myelin Oligodendrocyte Glycoprotein) antibody detection in Serum
    TAT 24 working hours
59. Multiple Sclerosis Evaluation Panel
    • Serum Albumin- quantitation
    • Serum IgG- quantitation
    • CSF Albumin- quantitation
    • CSF IgG -quantitation
    • CSF IgG index – formula-based calculation
    • CSF IgG synthesis rate- formula-based calculation
    • CSF IgG Intrathecal synthesis rate- formula-based calculation
    • Albumin index- formula-based calculation
    • Serum Oligoclonal Bands
    • 10.CSF Oligoclonal Band
      Paired Serum and CSF samples are necessary
      CSF sample to be collected in polypropylene tube
      TAT 10 working days
60. MuSK (Muscle Specific Tyrosine Kinase) antibody quantitation in Serum

TAT 7 working days

61. Myasthenia Gravis antibodies Evaluation Panel in Serum
    • Acetylcholine Receptor autoantibody quantitation
    • Agrin antibody quantitation
    • LRP4 (Low density Lipoprotein Receptor related Protein 4) antibody quantitation
    • MuSK (Muscle Specific Tyrosine Kinase) antibody quantitation
    • Ryanodine receptor antibody quantitation
    • Striatal Muscle antibody detection (Qualitative)
    • Titin antibody quantitation
      TAT 7 working days
62. Neurexin – 3 alpha antibody detection in CSF
    TAT 48 working hours
63. Neurexin – 3 alpha antibody detection in Serum
    TAT 48 working hours
64. Neurochondrin antibody detection in CSF
    TAT 48 working hours
65. Neurochondrin antibody detection in Serum
    TAT 48 working hours
66. Neurofascin 140 antibody quantitation in CSF
    TAT 7working days
67. Neurofascin 140 antibody quantitation in Serum
    TAT 7working days
68. Neurofascin 155 antibody quantitation in CSF
    TAT 7working days
69. Neurofascin 155 antibody quantitation in Serum
    TAT 7working days
70. Neurofascin 186 antibody quantitation in CSF
    TAT 7working days
71. Neurofascin 186 antibody quantitation in Serum
    TAT 7working days
72. Neurofilament Light Polypeptide quantitation in CSF
    TAT 7 working days
73. Neurofilament Light Polypeptide quantitation in Serum
    TAT 7 working days
74. NMOSD (Neuromyelitis Optica Spectrum Disorders) antibody panel detection in CSF
    • Myelin Oligodendrocyte Glycoprotein (MOG)
    • NeuromyelitisOptica (NMO/Aquaporin-4)
      TAT 24 working hours
75. NMOSD (Neuromyelitis Optica Spectrum Disorders) antibody panel detection in Serum
    • 1.Myelin Oligodendrocyte Glycoprotein (MOG)
    • 2 NeuromyelitisOptica (NMO/Aquaporin-4)
      TAT 24 working hours
76. Neuron Specific Enolase quantitation in CSF
    TAT 7 working days
77. Neuron Specific Enolase quantitation in Serum
    TAT 7 working days
78. Neuronal antibody detection in CSF
    TAT 48 working hours
79. Neuronal antibody detection in Serum
    TAT 48 working hours
80. NIF (Neuronal Intermediate Filament) detection in CSF
    TAT 48 working hours
81. NIF (Neuronal Intermediate Filament) detection in Serum
    TAT 48 working hours
82. NMDA (N- methyl –D-aspartate) NR-1 receptor antibody detection in CSF
    TAT 24 working hours
83. NMDA (N- methyl –D-aspartate) NR-1 receptor antibody detection in Serum
    TAT 24 working hours
84. NMO-IgG (Aquaporin-4) antibody detection in CSF
    TAT 24 working hours
85. 85. NMO-IgG (Aquaporin-4) antibody detection in Serum
    TAT 24 working hours
86. Oligoclonal band in CSF profile
    • CSF albumin quantitation
    • CSF IgG quantitation
    • CSF IgG/CSF Albumin ratio
    • CSF Oligoclonal Bands
      CSF sample to be collected in polypropylene tube
      TAT 10working Days
87. Orexin – A quantitation in CSF
    TAT 7 working days
88. Paraneoplastic panel of neuronal antibody detection in CSF
    • ANNA-1(anti-Hu) Anti Neuronal Nuclear Antibody1
    • ANNA-2 (anti-Ri) Anti Neuronal Nuclear Antibody 2.
    • ANNA-3 Anti Neuronal Nuclear Antibody 3.
    • AGNA-1 Anti Glial Nuclear Antibody-1.
    • PCA-1 (anti-Yo) Purkinje cell Cytoplasmic Antibody-1.
    • PCA-2 Purkinje Cell Cytoplasmic Antibody-2.
    • PCA-Tr Purkinje Cell Cytoplasmic Antibody-Tr.
    • Amphiphysin Antibody                
    • CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody
    • Ma2/Ta Antibody.
      TAT 24 working hours
89. Paraneoplastic panel of neuronal antibody detection in Serum

• CRMP-5{Collapsin Response Mediator Protein-5} (CV-2) Antibody
• Amphiphysin Antibody
• PCA-Tr Purkinje Cell Cytoplasmic Antibody-Tr.
• PCA-2 Purkinje Cell Cytoplasmic Antibody-2.
• PCA-1 (anti-Yo)  Purkinje Cell Cytoplasmic Antibody-1.
• AGNA-1 Anti Glial Nuclear Antibody-1.
• ANNA-3 Anti Neuronal Nuclear Antibody 3.
• ANNA-2(anti-Ri) Anti Neuronal Nuclear Antibody 2.
• ANNA-1(anti-Hu) Anti Neuronal Nuclear Antibody1
• Ma2/Ta Antibody.
  TAT 24 working hours

90. 14-3-3 Protein Gamma quantitation in CSF
    CSF sample to be collected in polypropylene tube
    TAT 7 Working days
91. Recoverin antibody detection in CSF
    TAT 48 working hours
92. Recoverin antibody detection in Serum
    TAT 48 working hours
93. Reflex to titer assay for MOG (Myelin Oligodendrocyte Glycoprotein) antibody detection in CSF
    TAT 48 working hours
94. Reflex to titer assay for MOG (Myelin Oligodendrocyte Glycoprotein) antibody detection in Serum
    TAT 48 working hours
95. Reflex to titer assay for NMDA (NR-1) Receptor antibody detection in CSF
    TAT 48 working hours
96. Reflex to titer assay for NMDA (NR-1) Receptor antibody detection in Serum
    TAT 48 working hours
97. Reflex to titer assay for NMOSD (Neuromyelitis Optica Spectrum Disorders) antibody detection in CSF

• Myelin Oligodendrocyte Glycoprotein (MOG)
• Neuromyelitis Optica (NMO/Aquaporin-4)
  TAT 48 working hours

98. Reflex to titer assay for NMOSD (Neuromyelitis Optica Spectrum Disorders) antibody detection in Serum

• Myelin Oligodendrocyte Glycoprotein (MOG)
• Neuromyelitis Optica (NMO/Aquaporin-4)
  TAT 48 working hours

99. Reflex to titer assay for VGKC (Voltage-gated potassium channel) antibody detection in CSF

• LGI-1 (Leucine-rich glioma inactivated protein -1) Antibody (VGKC associated)
• CASPR-2 (Contactin-associated protein-2) Antibody (VGKC associated)
  TAT 48 working hours

100. Reflex to titer assay for VGKC (Voltage-gated potassium channel) antibody detection in Serum

• LGI-1 (Leucine-rich glioma inactivated protein -1) Antibody (VGKC associated)
• CASPR-2 (Contactin-associated protein-2) Antibody (VGKC associated)
  TAT 48 working hours

101. Ryanodine receptor antibody quantitation in Serum
     TAT 7 working days
102. 102. Septin 5 antibody detection in CSF
     TAT 48 working hours
103. Septin 5 antibody detection in Serum
     TAT 48 working hours
104. SEZ6L2 (Seizure related 6 homolog like 2) antibody detection in CSF
     TAT 48 working hours
105. SEZ6L2 (Seizure related 6 homolog like 2) antibody detection in Serum
     TAT 48 working hours
106. Stiff- Person Spectrum Disorders Antibody Evaluation panel in CSF

• Amphiphysin antibody
• GAD 65 antibody
• Glycine Receptor antibody
• Gephyrin
• GABA A receptor antibody
• DPPX Antibody
• IgLON5 antibody
  TAT 48 working hours

107. Stiff- Person Spectrum Disorders Antibody Evaluation panel in Serum

• Amphiphysin antibody
• GAD 65 antibody
• Glycine Receptor antibody
• Gephyrin
• GABA A receptor antibody
• DPPX Antibody
• IgLON5 antibody
  TAT 7 working days

108. Striational (Striated Muscle) antibody detection in Serum
     TAT 48 working hours
109. Sulfatide antibody IgM quantitation in Serum
     TAT 7 working days
110. Titin antibody detection in Serum (Qualitative)
     TAT 48 working hours
111. Titin antibody quantitation in Serum
     TAT 7 working days
112. 112. VGCC IgG (Voltage-gated Calcium Channel) antibody quantitation in Serum
     TAT 7 working days
113. VGKC (Voltage-gated potassium channel) antibody detection in CSF

• LGI-1(Leucine-rich glioma- inactivated Protein-1) Antibody (VGKC associated)
• CASPR-2 (Contactin-associated protein-2) Antibody (VGKC associated)
  TAT 24 working hours

114. VGKC (Voltage-gated potassium channel) antibody detection in Serum

• LGI-1 (Leucine-rich glioma inactivated protein -1) Antibody (VGKC associated)
• CASPR-2 (Contactin-associated protein-2) Antibody (VGKC associated)
  TAT 24 working hours

115. Zic 4 antibody detection in CSF
     TAT 48 working hours
116. Zic 4 antibody detection in Serum
     TAT 48 working hours

 *Reflex to titer assay

End point titer will be performed at an additional charge upon request from your treating consultant.

Purpose of recommendation for Reflex to titer assay in antibody-positive cases.

1.Reflex to titer is a measure of the amount of antibody in serum and CSF; the higher the titer, the higher the autoantibodies present in the samples.
 

2.Reflex-to-titer assay is used in monitoring treatment response in autoantibody-positive patients. Decreasing antibody titer may be associated with good therapeutic response, so clinical correlation must be strongly considered.

* Laboratory working time 9.00 am to 6.00 pm. (Except Sundays and Institute Holidays)

Specimen: Serum (Volume Two ml)      Specimen: CSF (Volume One ml)

CSF Sample collection in sterile leak proof, polypropylene/ plastic tube

Serum collection in 5 ml blood in Red cap vacutainer(Clotted blood) or yellow cap(Gel)

Please send relevant clinical information, investigation details, name, phone number, email, and contact address of referring physician. As part of quality assurance, the following information needs to be provided:

Date of collection of sample Date/Time to send the sample

Method of sample transportation

1. Use a screw top, leak proof container.
2. Sample is stable at ambient temperature for 72 hours.
3. Samples sent by courier, should reach the lab within 72 hours
4. 4.Avoid sending the sample at weekends to reduce the transport time to less than 72 hours.
5. If any delay is expected, send samples refrigerated at 4°Cwhich is stable upto 14 days.
6. Store sample in a refrigerator until sending.
7. In case of small sample volume or any other problem, contact lab before sending.

Please ensure samples are accompanied by completely filled Test Request Form (TRF) along with payment details. Avoid sending samples of different patients together. Separate them by using different Zip lock pouches.

Payment options

1.Cash payment at the Billing Counter at Amrita Institute of Medical Sciences directly

2.*Demand Draft in favor of Amrita Institute of Medical Sciences payable at Kochi/ Ernakulam
3.*Online / Internet Fund Transfer National Electronic Fund Transfer (NEFT)

Account Name: Amrita Institute of Medical Sciences and Research Centre

Account No: 015500100001304

Address:Amrita Lane, AIMS Ponekkara.P.O., Ernakulam, Kerala State, India. Pin Code: 682041

Bank Name: The Dhanalakshmi Bank Limited, AIMS Campus, Amrita Lane, AIMS Ponekkara.P.O, Ernakulam, Kerala State, India. Pin Code 682041.

Bank SWIFT Code:DLXBINBB

Bank RTGS/IFSC Code:DLXB0000155

*Please provide DD details/Bank transaction ID details with test request form.

Bank Transfer details

Reference :- Patient Name and MRD No

Transfer details required for accounting purpose

Senders Name

Senders Bank Name

Date of transaction

Place of Senders

bank Amount of

Transfer

UTR No and transaction ID

Details submitted by

Patient Name and MRD No:-

Details submitted by

After transaction kindly send the UTR number / Transaction Number to these mail id neuroimmunology @aims.amrita .edu and [email protected] and [email protected]

• http://www.pnseuronet.org/
• http://www.esni.org/
• http://www.birmingham.ac.uk/facilities/clinical-immunology-services/neuroimmunology/index.aspx
• http://www.isniweb.org/

Address: Dr.Sudheeran Kannoth, Neuroimmunology laboratory (T6F3) Amrita Institute of Medical Sciences(Amrita Hospital), Ponekkara PO 682041, or Elamakkara PO 682026 Kochi, Kerala, India
Phone:+91 484 285 1234, 0484 6681234 Extension - 6304 & 6318
Mobile: 09400998656
Email: [email protected]

"ZeiniX Life Sciences is the official industry partner of the Neuroimmunology Laboratory at Amrita Institute of Medical Sciences, Cochin. For all commercial inquiries including MoUs and sending samples, please contact ZeiniX at [email protected] or +91 88677 59300. No other laboratory, company or individual is authorized to collect samples on our behalf."