Dr. Annamma Mathai

Dr. Annamma Mathai is a trained immunopathologist from Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh. She has worked as a scientist in Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram for more than three and a half decades, on immunopatholgy and diagnostic immunology of neurotuberculosis as well as autoimmune neurological disorders.

• Sudheeran Kannoth, Anandkumar Anandakuttan, Annamma Mathai, Anuja Nirmala Sasikumar & Vivek Nambiar. Autoimmune atypical parkinsonism -A group of treatable parkinsonism. Journal of Neurological Sciences;2016 362:40-46
• Asha Caroline Cyril, Sruthi S. Nair, Annamma Mathai, Sudheeran Kannoth &Sanjeev V Thomas ,Autoimmune encephalitis:Clinical diagnosis versus antibody confirmation. .Annals of Indian Academy of Neurology, 2015, 18(4) 408-411
• Sanjeev V Thomas, P S. Sarma, C. Nirmala, Annamma Mathai, Sara E Thomas, & Asha C Thomas. Women with epilepsy and infertility have different reproductive hormone profile than others .Annals of Indian Academy of Neurology, 2013;16(4):544-548
• Annamma M, Neelima R, Harikrishnan V.S, Radhakrishnan VV. Trehalose 6,6’ dimycolate (cord factor) induced pulmonary granuloma in naïve and lymphopenic mice. J Infect Dis Immun: 2012; 4 (3):29-35.
• Annamma M, Neelima R, Harikrishna V.S, Radhakrishnan VV. An immuno assay using cord factor for the confirmatory diagnosis of intracranial tuberculoma. J. Infect DIS Immun: 2011:3:64-67.
• Annmma M, Neelima R, Nair MD, Radhakrishnan VV. Utility of cord factor antigen of Mycobacterium tuberculosis for the laboratory diagnosis of tuberculous meningitis. Int Res J Microbiol 2011, 2:167-172
• Sumi S, Madhavilathe GK, Sathish M, Annmma M, Radhakrishnan VV. Assessment of four recombinant mycobacterial antigens as serodiagnostic markers of pulmonary tuberculosis. J Clin Med Res 2009; 1 (3) 35-40
• Radhakrishnan V.V, Sumi MG, Reuben S, Annamma M, Nair MD: Serum tumor necrosis factor-alpha and soluble tumor necrosis factor receptors levels in patients with Guillain-Barre syndrome. Acta Neurologica Scand. 2004;109(1):71-74
• Radhakrishnan V.V, Sumi MG, Reuben S, Annamma M, Nair MD: Circulating tumour necrosis factor alpha (TNF-µ) and soluble tumour Necrosis factor (TNF) receptors in patients with Guillain Barre Syndrome. Indian J. Medical Res. 2003;117:216-220
• Reuben S, Sumi MG, Annamma M, Nair MD, Radhakrishnan V.V.: Intravenous immunoglobulin reduces Tumour Necrosis Factor alpha in patients with Guillain Barre syndrome. Neurol India. 2003;51(4):487-489
• Annamma M, Radhakrishnan V.V., Sarada C, George S.M: Detection of heat stable mycobacterial antigen in cerebrospinal fluid by Dot – Immunobinding assay. Neurol India 2003;51:52-54.
• Sumi MG, Annamma M, Reuben S, Sarada C, Radhakrishnan V.V, Indulakshmi R, Sathish M, Ajayakumar R, Manju Y.K. A comparative evaluation of dot immunobinding assay and polymerase chain reaction for the laboratory diagnosis of tuberculous meningitis. Diag. Microbiol Infect Dis 2002;42:35-38
• Sumi M.G, Annamma M, Reuben S, Sarada C, Radhakrishnan V.V. Immunocytochemical method for early laboratory diagnosis of Tuberculous meningitis. Clin Diag Lab Immunol 2002;9:344-347
• Reuben S, Annamma M, Sumi MG, Nair MD, Radhakrishnan V.V. Serum tumor necrosis factor – alpha in Guillain – Barre syndrome and its relation to plasma exchange. The Neurologist 2002;8:47-50.
• Annamma M, Radhakrishnan V.V. Sumi MG, Sarada C. A newer approach for the laboratory diagnosis of tuberculous meningitis Diag Microbiol Infect Dis 2001;39:225-228.
• Sumi MG, Annamma M, Reuben S, Radhakrishnan V.V. A Dot immunobinding assay for rapid diagnosis of pulmonary tuberculosis. Indian J Exp Biol 2001, 39:984-988.
• Sumi MG, Annamma M, Sheela R, Radhakrishnan NS, Radhakrishnan V,V, Indulekshmy R, Mundayoor S. Diagnostic techniques for the laboratory diagnosis of intracranial tuberculoma. Clin Neuropathol 2001,20,176-180
• Reuben S, Annamma M, Sumi MG, Nair MD, Radhakrishnan V.V. Significiance of serum antibody to GD1b ganglioside in patients with Gullain Barre syndrome. Indian J Med Res 2001; 113-234-238.
• Annamma M, Sarada C, Radhakrishnan V.V. Significance of circulating immune complexes in Myasthenia gravis. Indian J Med Res 2000;111:180-183
• Sumi MG, Annamma M, Sarada C, Radhakrishnan V.V. Rapid diagnosis of Tuberculous meningitis by a dot – immunobinding assay. Acta Neurol Scand 2000, 101:61-64.
• Annamma M, Sarada C, Radhakrishnan V.V. An enzyme linked immunosorbent assay for antibodies against acid soluble skeletal muscle antigen in Myasthenia gravis. Acta Neurol Scand 1999;100:175-177
• Sumi MG, Annamma M, Sarada C, Radhakrishnan V.V. Rapid diagnosis of Tuberculous Meningitis by a DOT immunobinding assay to detect Mycobacterial antigen in cerebrospinal fluid specimens. J Clin Microbiol 1999,37:3925-3927
• Annamma M, Radhakrishnan V.V. Characterization of Mycobacterial antigens by ELISA and immunoblot methods. India J Pathol Microbiol 1995;38:299-303.
• Annamma M, Radhakrishnan VV, Sehgal S. Diagnosis of tuberculous meningitis confirmed by means of an immunoblot method. J. Infect 1994;29:33-39.
• Radhakrishnan V.V. Annamma M, Mohan PK. Diagnosis of tuberculous meningitis by enzyme linked immunosorbent assay using an affinity chromatography purified mycobacterial antigen. J Assoc Phy India 1994;42:684-687.
• Radhakrishnan V,V, Annamma M. Correlation between the isolation of mycobacterium tuberculosis and estimation of mycobacterial antigen in cisternal, ventricular and lumbar cerebrospinal fluids of patients with tuberculous meningitis. Indian J Pathol Microbiol 1993;36:341-347.
• Tharakan JAK, Mathai J, Annamma M, Sulochana PV. Immune complex levels and plasmapheresis in Guillain Barre Syndrome. Acta Neurologica 1993;15:138-141.
• Sundaram P, Annamma M, Radhakrishnan V.V. Detection of IgG antibody to Mycobacterium tuberculosis antigen 5 by ELISA in sera of patients with Pulmonary tuberculosis. Indian J Allergy Appl Immunol 1993;7:29-33.
• Radhakrishnan V.V, Annamma M, Sundaram P, Diagnostic significance of circulating immune complexes in patients with pulmonary tuberculosis J. Med Microbiol 1992;36:128-131.
• Annamma M, Radhkrishnan V.V. Thomas M. Significance of IgG antibody of mycobacterium tuberculosis antigen 5 in CSF of patients with chronic meningitis. India J Med Microbiol 1992;10:94-100.
• Annamma M, Radhakrishnan V.V, Thomas M. Comparative evaluation of tuberculin purified protein derivative, commercial PPD and BCG in the laboratory diagnosis of tuberculous meningitis. J Assodc Phys India 1992;40:14-17.
• Annamma M, Radhakrishnan V.V, Thomas M. Rapid diagnosis of tuberculous meningitis with a Dot enzyme immuno assay to detect antibody in cerebrospinal fluid. European J Infect Dis and Clin Microbiol 1991;10:440-443.
• Annamma M, Radhakrishnan V.V. Circulating immune complexes in CSF of patient with Tuberculous Meningitis. Indian J Exp Biol 1991;29:973-976.
• Annamma M, Radhakrishanan V.V. Humoral Immune reactions in tuberculous meningitis. Indian J Med Sci 1991;45:233-238.
• Annamma M. Radhakrishnan V.V. Detection of mycobacterial antigen in cerebrospinal fluid by inhibition enzyme linked immunosorbent assay and its diagnostic application in Tuberculous meningitis. Indian J Med Microbiol 1991;9:16-21.
• Radhakrishnan V.V, Annamma M. Detection of mycobacterium tuberculosis antigen 5 in cerebrospinal fluid specimen by inhibition ELISA and its diagnostic potential in tuberculous meningitis. J Infect Dis 1991;163:650-652.
• Radhakrishnan V.V, Annamma M. Rapid serodiagnostic test for pulmonary tuberculosis. Indian J Exp. Biol 1991;29-448-451.
• Radhakrishnan V.V, Annamma M. Potential application of dot immunobinding assay as a rapid diagnostic test in tuberculous meningitis. Indian J Exp Biol 1991;29:437-440.
• Radhakrishnan V.V, Annamma M. Isolation of two antigens from the culture filtrates of mycobacterium tuberculosis and their applications in the laboratory diagnosis of tuberculous meningitis. Med Microbiol Immunol 1991;180:101-107.
• Radhakrishnan V.V, Annamma M, Radhakrishnan N.S. Rout D, Sehgal S. Immunohistochemical demonstration of mycobactrial antigens in intracranial tuberculoma. Indian J exp Biol 1991;29:641-644.
• Radhakrishnan V.V, Annamma M. A Dot-Immunobinding assay for the laboratory diagnosis of tuberculous meningitis and its comparison with ELISA. J Appl Bacateriol 1991;71:428-433.
• Radhakrishnan V.V, Annamma M, Thomas M. Correlation between culture of M. Tuberculosis and antimycobacterial antibody in lumbar, ventricular and cisternal cerebrospinal fluids of patients with tuberculous meningitis. Indian J Exp Biol 1991;29:845-848.
• Radhakrishnan V.V, Annamma M. Enzyme linked immunosorbent assay to detect mycobacterium tubeculosis antigen 5 and antimycobacterial antibody in CSF of patients with tuberculous meningitis. J Clin Lab Anal 1991;5:233-237.
• Annamma M, Radhakrishnan V.V, Sehgal S. IgG antibody to Mycobacterium tuberculosis antigen 5 in cerebrospinal fluid and its diagnostic application in tuberculous meningitis. Indian J exp. Biol 1990;28:816-820.
• Annamma M, Radhakrishnan V.V, Mohan PK, Sehgal S. ELISA of IgG antibody to mycobacterium tuberculous antigen 5, PPD in CSF in tuberculous meningitis patients. Indian J Med Res 1990;91:425-430.
• Radhakrishnan V.V, Annamma M. Detection of mycobacterial antigen in cerebrospinal fluid; diagnostic and prognostic significance. J Neurol Science 1990;99:93-99.
• Radhakrishnan V.V, Sehgal S, Annamma M. Correlation between culture of mycobacterium tuberculosis and detection of mycobacterial antigen in cerebrospinal fluid of patients with tuberculous meningitis. J Med Microbiol 1990;33:223-226.
• Radhakrishnan V.V, Annamma M, Sehgal S. Correlation between culture of Mycobacterium tuberculosis and IgG antibody to Mycobacterium tuberculosis antigen 5 in the cerebrospinal fluid of patients with tuberculous meningitis. J Infect 1990;21:271-277.
• Radhakrishnan V.V, Annamma M, Rao SB, Sehgal S. Immunoelectrophoresis of mycobacterial antigens. Indian J Exp. Biol 1990;28:812-815.
• Annamma M Radhakrishnan V.V,Sehgal S. Diagnosis of tuberculous meningitis by an enzyme linked immunosorobent assay to detect mycobacterial antigen and antibody in cerebrospinal fluid. Med Microbiol Immunol 1990;179:281-288.
• Radhakrishnan V.V, Annamma M, Mohan PK, Sehgal S. Correlation between culture positivity for Mycobacterium tuberculosis and IgG antibody to Mycobacterium tuberculosis antigen 5 in CSF of patient with Tuberculous Meningitis. Neurol India, 1990;38:537-544.
• Annamma M ,Radhakrishnan V.V, Sehgal S, Mohan P.K. Enzyme linked immunosorbent assay for IgG antibody to tuberculin purified protein derivative in cerebrospinal fluid specimens of patients with tuberculous meningitis. Indian J Med Microbiol 1989;7:98-104.
• Annamma M ,Radhakrishnan V.V, Rao SB. Isolation of Mycobacterium tuberculosis antigen 5 by immunoabsorbent affinity chromatography and its diagnostic application in tuberculous meningitis. Indian J Med Microbio, 1989;7:49-53.
• Annamma M, Kartha CC, Balakrishan KG, Serum Immunoglobulin in patients with endomyocardial Fibrosis. Indian Heart J 1986;38:470-472.
• Kartha CC, Annamma M, Balakrishnan KG, Valiathan MS. Immunohistological studies in Endomyocardial Fibrosis. Indian Heart J 1984;36:90-91.
• Radhakrishnan V.V, Annamma M. Role of hyaluronidase in invitro phagocytosis of encapsulated yeast of Cryptococcus neoformans. Indian J Exp Biol 1983;21:285-288.
• Radhakrishnan V.V, Annamma M. Hyaluronidase and circulating Cryptococcal capsular polysaccharide titre. Indian J Exp Biol 1983. 21:557-559.
• Radhakrishnan V.V, Annamma M, Shanmugham J, Mathew GJ. The role of hyaluronidase in experimental Cryptococcal infections. Surg Neurol 1982;17:239-244.